Breast cancer
Elevated levels of MMP-1–3, MMP-7–9, MMP-11, MMP-
13–15, and MMP-26 are reported in the blood, urine, and/or
cancer tissue from breast cancer patients [90–95]. [96]. Furthermore, strong immunohistochemical
staining for MMP-1 in stromal fibroblasts has been associ-
ated with a higher rate of distant metastases [97, 98]. The
level of MMP-2 does not seem to have any liable prognostic
value, whereas strong MMP-9 expression in stromal cells
has been associated with poor prognosis in several studies
[96–100].