3 All six E. coli isolates assayed possessed two mutations in gyrA and a single mutation in parC resulting in alterations at codons Ser-83 and Asp-87 in GyrA and codons 80 or 84 in ParC, respectively (Table 1). The majority of isolates displayed Ser-83 !Leu and Asp-87 !Asn alterations in GyrA and a Ser-80!Ile alteration in