Other studies evaluating the relationship between preeclampsia and dNK cell numbers and phenotype have
produced conflicting results.
58
However, as noted by Lash
and Bulmer,
58
the lack of clarity among various studies as to
whether dNK cell numbers are reduced in preeclampsia and
intrauterine growth restriction likely reflects differences in
sampling, analysis, and severity of the disease. Beyond
altered dNK cell numbers, preeclampsia, as well as other
adverse pregnancy outcomes, such as fetal growth restriction and recurrent miscarriage, are associated with mismatched KIR haplotype (KIR AA) expression by dNK cells
and EVTs