Color inhomogeneity is a known issue in serial cryosections, but there has not been a simple and effective method to solve this problem yet. A new method is proposed to reduce color inhomogeneities in this study, which is based on color transfer technique. It takes advantage of the similarity of adjacent images in image series. The new method can unify the color styles of adjacent slices to achieve the color homogenization of the image series. The color correction process of our method only needs the calculation of mean and standard deviation of pixels of the image. So the new method is simple and highly-efficient. By the multiplanar reformation images, the experimental result shows that the new method has a good performance.