326. Semin Radiat Oncol. 2000 Oct;10(4):296-307.
The physical parameters and molecular events associated with radiation-induced
lung toxicity.
Vujaskovic Z(1), Marks LB, Anscher MS.
Author information:
(1)Department of Radiation Oncology, Duke University Medical Center, Durham, NC
27710, USA. vujaskovic@radonc.duke.edu
Radiation therapy (RT) is frequently used to treat patients with tumors in and
around the thorax. Clinical radiation pneumonitis is a common side effect,
occurring in 5% to 20% of patients. Efforts to identify patients at risk for
pneumonitis have focused on physical factors, such as dose and volume. Recently,
the underlying molecular biological mechanisms behind RT-induced lung injury have
come under study. Improved knowledge of the molecular events associated with
RT-induced lung injury may translate into a better ability to individualized
therapy. This review discusses our current understanding of the physical and
molecular factors contributing to RT-induced pulmonary injury.
Copyright 2000 by W.B. Saunders Company.
PMID: 11040330 [PubMed - indexed for MEDLINE]
326. Semin Radiat Oncol. 2000 Oct;10(4):296-307.The physical parameters and molecular events associated with radiation-inducedlung toxicity.Vujaskovic Z(1), Marks LB, Anscher MS.Author information: (1)Department of Radiation Oncology, Duke University Medical Center, Durham, NC27710, USA. vujaskovic@radonc.duke.eduRadiation therapy (RT) is frequently used to treat patients with tumors in andaround the thorax. Clinical radiation pneumonitis is a common side effect,occurring in 5% to 20% of patients. Efforts to identify patients at risk forpneumonitis have focused on physical factors, such as dose and volume. Recently, the underlying molecular biological mechanisms behind RT-induced lung injury havecome under study. Improved knowledge of the molecular events associated withRT-induced lung injury may translate into a better ability to individualizedtherapy. This review discusses our current understanding of the physical andmolecular factors contributing to RT-induced pulmonary injury.Copyright 2000 by W.B. Saunders Company.PMID: 11040330 [PubMed - indexed for MEDLINE]
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